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PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

As resistance to existing antibiotics increases, new approaches to serious bacterial infections are needed. Now researchers have investigated one such alternative.
The protein Roquin plays a key role in the regulation of immune reactions. Researchers have now uncovered details of the mechanism by which it controls the function of regulatory T cells in the adaptive arm of the immune system.
The more a poem evokes vivid sensory imagery, the more we like it.
By using an electrochemical etching process on a common stainless steel alloy, researchers have created a nanotextured surface that kills bacteria while not harming mammalian cells. If additional research supports early test results, the process might be used to attack microbial contamination on implantable medical devices and on food processing equipment made with the metal.
Scientists have developed new technology to detect the activity of RNase H, a RNA degrading enzyme. The team used highly efficient signal amplification reaction termed catalytic hairpin assembly (CHA) to effectively analyze the RNase H activity. Considering that RNase H is required in the proliferation of retroviruses such as HIV, this research finding could contribute to AIDS treatments in the future, researchers say.
How sensitive is the human sense of touch? Sensitive enough to feel the difference between surfaces that differ by just a single layer of molecules, a team of researchers has shown. Researchers say this fundamental knowledge will be useful for developing electronic skin, prosthetics that can feel, advanced haptic technology for virtual and augmented reality and more.
Researchers report that endocytosis, which was previously thought to be a random process, actually occurs in a coordinated manner through collective dynamics. The work showed how a major endocytic pathway mediated by the protein clathrin, was found to commence with periodic traveling waves of clathrin, which were coupled temporally and spatially to downstream cortical actin waves. Clathrin endocytic waves were identified as the upstream initiator of cortical actin waves.
Researchers have discovered how high glucose levels -- whether caused by diabetes or other factors -- keep heart cells from maturing normally. Their findings help explain why babies born to women with diabetes are more likely to develop congenital heart disease.
A protein transferred from male to female mosquitoes during sex influences female mating behavior -- a phenomenon that could be exploited to limit the spread of mosquito-borne illnesses like Zika and dengue.
The secrets of the circadian rhythms in red blood cells have been identified by researchers who have also identified potassium as the key to unraveling the mystery.  
Public health messaging about the safety of e-cigarettes needs to account for the worldviews of the target audience, with different groups displaying varying levels of trust depending on the source of the message, according to a recent study.
Experts have published a new study on the mechanisms that regulate cell division and guarantee the correct distribution of chromosomes during this process. In particular, they especially highlight the fundamental role that an organelle, specifically the nucleolus, plays in the coordination of these processes.
In working life it's now almost expected that employees answer work-related emails after hours, or take their laptops with them on holiday. But the blurring of boundaries between work and personal life can affect people's sense of well-being and lead to exhaustion.
'G-g-g-g-g-ood morning' is a daily obstacle for people who stutter. However, so far, not much is known about the causes of persistent developmental stuttering, which is the most frequent speech disorder. Scientists have recently discovered that a hyperactive network in the right frontal part of the brain plays a crucial role in this deficit. It inhibits speech movement planning and execution, thereby interrupting the flow of speech.
Medical researchers have discovered a new avenue through which to attack prostrate cancer cells that have developed drug-resistance.
Bipolar disorder may involve accelerated epigenetic aging, which could explain why persons with the disorder are more likely to have -- and die from -- age-related diseases, according to researchers.
Much as a frame provides structural support for a house and the chassis provides strength and shape for a car, a team of engineers believes they have a way to create the structural framework for growing living tissue using an off-the-shelf 3-D printer.
A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a new study.
Estrogen produced in the brain is necessary for ovulation in monkeys, according to researchers who have upended the traditional understanding of the hormonal cascade that leads to release of an egg from the ovaries. Their findings may reveal the cause of some undiagnosed infertility problems and point the way to new methods of birth control.
Cancer imaging can be simplified by a photonic process utilizing molecules derived from horse chestnuts, research shows.
Different types of privacy laws in US states produce markedly different effects on the willingness of patients to have genetic testing done, according to a new study.
Researchers have found fresh evidence to explain the processes that occur in the body's cells leading to the onset of type2 diabetes.
The NEIL3 enzyme has long been known to repair ‘day-to-day’ oxidative damage to DNA that is implicated in diseases of ageing, including dementia and cancer.
Using light-emitting nanoparticles, scientists have invented a highly effective method to detect tiny tumors and track their spread, potentially leading to earlier cancer detection and more precise treatment. The technology could improve patient cure rates and survival times.
Researchers have found a mechanism through which certain types of leukemia resist chemotherapy, revealing novel molecular targets to improve this therapy's efficiency.
Video games may have a reputation for attracting introverts, but when it comes to augmented reality games like Pokémon Go, extroverts tend to be better players. That's the key finding of a new psychology study, the first to look at the impact of players' personalities, social competence and social anxiety when playing the hit mobile game.
Researchers identify a promising avenue for improving treatments for people with cystic fibrosis. They found that adding molecules called quorum-sensing inhibitors to current drugs not only reduces bacterial production of certain harmful residues but also restores the efficacy of existing treatments, such as Orkambi and Kalydeco, on the cells of cystic fibrosis patients. This breakthrough paves the way for new personalized therapies.
The human brain learns and adapts. Numerous research studies have focused on the impact of action video games on the brain by measuring cognitive abilities, such as perception and reaction time. An international team of psychologists has assembled data from the last fifteen years to quantify how action video games impact cognition. The research has resulted in two meta-analyses, which reveal a significant improvement in the cognitive abilities of gamers.
A new study reports which epigenetic factors in certain chromosomes that make one twin more at risk for autoimmune thyroid diseases.
Researchers have found a key protein (Skn-1a) acts as a master regulator for the generation of chemosensory cells in mice. As these cells are known to detect bitter or toxic substances, the study provides insights into the body's innate defense mechanisms and could lead to the development of new drugs in future.
Scientists have sequenced the genetic makeup of 24 South African individuals of different ethnolinguistic origins. The first government-funded human genomics research study performed on African soil, aimed at unlocking the unique genetic character of southern African populations, has revealed a high level of genetic diversity.
A chemical found in marijuana, known as tetrahydrocannabinol, or THC, has been found to potentially slow the process in which mental decline can occur in up to 50 percent of HIV patients, says a new study.
A new therapy aimed at helping young people suffering from schizophrenia to reconnect and engage with the world around them has had promising results, according to a new study.
An analysis of 16 audiotaped conversations between parents of infants in a neonatal intensive care unit (NICU) and clinicians found that medical staff routinely downplay quality of life issues and leave families more optimistic about their babies' prognoses than the clinicians intended.
Research suggests bond duration, not bond tightness, may be the most important differentiator between antibiotics that kill bacteria and antibiotics that only stop bacterial growth.
In remote Italian villages nestled between the Mediterranean Sea and mountains lives a group of several hundred citizens over the age of 90. Researchers have identified common psychological traits in members of this group.
Most providers willing to consider medical marijuana use in children with cancer, but those with legal eligibility to certify are less likely to approve.
Immune responses and the regulation of autoimmunity are affected by the time of day when the response is activated. There may be important differences in time-of-day response to drugs used to treat autoimmune diseases such as multiple sclerosis.
Parents and pediatricians know that reading to infants is a good thing, but new research shows reading books that clearly name and label people and objects is even better.
Shoppers increasingly consult online reviews before making holiday purchases. But how do they decide which reviewers to trust? Consumer trust in online reviews is influenced by spelling errors and typos, research shows. But how much those errors influence each consumer depends on the type of error and that consumer's general tendency to trust others.
Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report researchers.
Each year there are more than three million cases of cholera worldwide. Research now shows that giving a stronger single-dose of a live oral vaccine could be an effective tool in controlling outbreaks more quickly.
A cost analysis shows treatment plans that set individualized blood sugar goals for diabetes patients, tailored to their age and health history, can save $13,546 in health care costs over their average lifetime when compared with treatment strategies that stick to a uniform national standard.
Limiting a much-needed resource could pit pathogens against one another and prevent the emergence of drug resistance. New research demonstrates that harnessing competition among pathogens inside a patient could extend the life of existing drugs where resistance is already present and prevent resistance to new drugs from emerging.
Gene editing has begun to be tested in clinical trials, using CRISPR-Cas9 and other technologies to directly edit DNA inside people's cells, and multiple trials are recruiting or in planning. A new study raises a note of caution, finding person-to-person genetic differences that may undercut the efficacy of gene editing or, more rarely, cause potentially dangerous 'off target' effects. It suggests that gene editing may need to be adapted to each patient's genome.
Sensory hair cells in the inner ear combine into hair bundles to convert sound waves into electrical signals. Both single-cell and organ-wide directionality are critical for hearing, but these two levels of organization are controlled by largely distinct molecular mechanisms during inner ear development. Researchers have identified a protein, Daple, that interacts with both systems and is a promising candidate to coordinate single cell and organ-wide directionality.
Analyzing trends on Twitter and Google can help predict vaccine scares that can lead to disease outbreaks, according to a study from the University of Waterloo.
Are societies more or less violent today than they were thousands of years ago? It's a matter of scale, researchers show. In a new study, researchers present an expanded data set showing that the larger the population of a society, the smaller its war group size, proportionally, and the fewer casualties in a conflict.
A team of researchers has identified a specific genetic change that may be the cause of a rare but severe neurological disorder called X-linked dystonia parkinsonism.
Individually most people only want to live long lives if they will be healthy, according to a new study.
Luke Skywalker's bionic hand is a step closer to reality for amputees in this galaxy. Researchers have created an ultrasonic sensor that allows amputees to control each of their prosthetic fingers individually. It provides fine motor hand gestures that aren't possible with current commercially available devices.
Initial findings from a multi-national open-label phase Ib study of inhibitory drug therapy for relapsed or refractory acute myeloid leukemia (AML) have demonstrated a complete response in up to 50 percent patients say researchers.
New research suggests bacterial genomes hold the blueprints for designing new, even more effective cancer-targeting compounds.
Microblogging may be a valuable online tool for reducing negative emotions for people who experience social anxiety, suggests new research.
People who are exposed to others who disagree with their views are more likely to let go of pre-existing biases, research shows.
An alternative animal model that mimics key features of the Zika virus infection, including its lingering presence in bodily fluids, has been developed.
A statistical approach to combining presurgical PET scans and functional MRI of the brain may help predict which patients with drug-resistant epilepsy are most likely to benefit from surgery.
Patients receiving long-term opioid therapy for chronic pain sometimes demonstrate challenging and concerning behaviors, such as using more opioid medication than prescribed or concomitant alcohol or drug use. A new study establishes expert consensus about treatment approaches that should be implemented when these behaviors arise.
Although the insidious bacterium Salmonella typhi has been around for centuries, very little is actually known about its molecular mechanisms. A new study addresses this knowledge gap and may lead to novel, targeted treatments.
Epidemiological studies show that in utero fetal infection with the Zika virus (ZIKV) may lead to microcephaly, an irreversible congenital malformation of the brain characterized by an incomplete development of the cerebral cortex. However, the mechanism of Zika virus-associated microcephaly remains unclear. Scientists have now identified a specific mechanism leading to this microcephaly.

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