The types of snacks a child chooses could be linked to genetics, a new study found. The study investigated whether genetic variants in taste receptors related to sweet, fat and bitter tastes influence the snacks preschoolers choose and found nearly 80 per cent carried at least one of these genotypes that could predispose them to poor snacking habits. These findings could help parents tailor their kids' diets based on their genetics of taste.
A research team has discovered the process -- and filmed the actual moment -- that can change the body's response to a dying cell. Importantly, what they call the 'Great Escape' moment may one day prove to be the crucial trigger for autoimmune diseases like arthritis.
Schizophrenia may be related to neurodevelopment changes, including brain's inability to create the appropriate vascular system, according to new study. The results broaden the understanding about the causes of this severe and disabling disorder, which affects about 1 percent of the world's population.
Glowing creatures like fireflies and jellyfish are captivating to look at but also a boon for science, as their bioluminescent molecules contribute to visualizing a host of biological processes. Now, scientists have supercharged these molecules, making them hundreds of times brighter in deep tissues and allowing for imaging of cells from outside the body. The bioengineered light source was used to track cancer cells in mice and brain-cell activity in monkeys, but its applications extend beyond the lab.
A living cell is able to neatly package a big jumble of DNA into chromosomes while preparing for cell division. For over a century, scientists have been puzzled for decades on how the process works. Researchers now managed for the first time to isolate and film the process, and witnessed -- in real time -- how a single protein complex called condensin reels in DNA to extrude a loop.
Between the brain's neurons and glial cells is a critical but understudied structure that's been called neuroscience's final frontier: the extracellular space. With a new imaging paradigm, scientists can now see into and study this complex fluid-filled matrix.
Chemists have developed a new catalytic method for symmetry breaking. The method can help synthesize important building blocks for bioactive compounds such as anticancer drugs.
The presence or absence of a unique brain signal after a listener has heard some speech indicates whether or not that listener has understood what has been said. The discovery has a number of practical applications, including tracking language development, assessing brain function post-injury, and confirming whether important instructions have been understood in high-pressure jobs.
A team of scientists has reported a more efficient approach to reprogramming a patient's diseased skin cells into stem cells, raising hopes for future clinical trials and potential cures for critical illnesses.
Researchers have discovered a new crosstalk between the migrating inhibitory interneurons and the stem cells that generate the excitatory neurons. The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice.
Contrary to previous studies and widespread belief, new research on competitive judo data finds a winning bias for the athlete who is first called, regardless of the color of their uniform.
Determining the three dimensional structure of the huntingtin protein could help develop new treatments for Huntington's disease.
Some scientists have hypothesized that tumor-promoting changes in cells during cancer development -- particularly an epigenetic change involving DNA methylation -- arise from rogue cells escaping a natural cell deterioration process called senescence. Now, researchers have demonstrated that instead, tumor-associated epigenetic states evolve erratically during early stages of tumor development, eventually selecting for a subset of genes that undergo the most changes during normal aging and in early tumor development.
Researchers have identified a key protein in old, poor-quality C. elegans eggs. When they blocked this protein midway through the fertile window, the equivalent of a woman in her early thirties, they successfully extended egg viability beyond the normal span. Another experiment that knocked out this protein's genes entirely extended the worms' fertility by about 10 percent. If applied to humans, that could represent a 3- to 6-year extension of female fertility.
Novel and robust process to produce functionalized giant unilamellar vesicles (GUVs) on-demand from double emulsions templates results in artificial cells with surface ligand neuroligin-2 (NL-2) to promote insulin secretion in pancreatic beta cells, demonstrating a versatile cell-cell synaptic therapeutic paradigm.
Scientists have demonstrated that the new neurons produced in adults react preferentially to reward-related sensory stimuli and help speed up the association between sensory information and reward. Adult-born neurons therefore play an important role in both the identification of a sensory stimulus and the positive value associated with that sensory experience. The neurons generated shortly after birth are unable to perform this function.
Inflammation needs energy: An important source for this energy is oxygen, which is indispensable for the cells of the immune system to work properly. On the one hand, oxygen is an essential element required for cells to survive; on the other hand, it also adds fuel to the fire of inflammation. Researchers have discovered that the body skilfully uses this process to extinguish inflammation.
To date, examining patient tissue samples has meant cutting them into thin slices for histological analysis. This might now be set to change, thanks to a new staining method. This allows specialists to investigate three-dimensional tissue samples using the Nano-CT system.
Researchers in Finland have discovered a new regulator of the immune system, a key factor that controls development of regulatory T cells. The discovery provides basis for new strategies for the treatment of both cancer and immune-mediated diseases.
Two papers published today look at the current evidence of the effects of medical marijuana laws and conclude there is little support that such laws increase recreational marijuana use among adolescents or reduce opioid overdose deaths.
Relating to oneself in a healthy way can help weaken the association between perfectionism and depression.
A child's growth and development is affected by the health and lifestyles of their parents before pregnancy -- even going back to adolescence -- according to a new paper.
Researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. This new mechanism involves two fully unstructured proteins forming an ultra-high-affinity complex due to their opposite net charge. Proteins usually bind one another as a result of perfectly matching shapes in their three-dimensional structures.
Researchers have uncovered a novel mechanism in which a protein--neuregulin 3--controls how key neurotransmitters are released in the brain during schizophrenia. The protein is elevated in people with schizophrenia and other severe mental illnesses, but the study is the first to investigate how it causes such severe mental illness.
The investigators used a technique called bottom-up proteomics (sometimes called shotgun proteomics) to reveal which proteins of each species were present in the hybrid flies.
Humans and fruit flies may have not shared a common ancestor for hundreds of millions of years, but the neurons that govern our circadian clocks are strikingly similar.
In the last eight years, the field of ancient DNA research has expanded from just one ancient human genome to more than 1,300. The latest 625 of those genomes debut Feb. 21 in Nature, including the largest study of ancient DNA to date.
The enzyme that produces DNA building blocks plays an important role when cells divide. In a new study, researchers have discovered for the first time that the so-called master switch of the enzyme can change locations -- while still performing the same task.
In the Christopher Nolan film Memento (2000) the protagonist suffers from long-term memory loss and is unable to retain new memories for no longer than a few minutes. The events unfold in reversed chronological order. The results deepen our understanding of how the brain functions, how narratives work in film, and memory mechanisms impaired by conditions such as Alzheimer's disease.
Drug addiction continues to plague vast numbers of people across the world, destroying and ending lives, while attempts to develop more effective pharmaceutical addiction treatments continue. Scientists now report the development of a potent new medicine to fight addiction, which might also be an effective treatment for epilepsy and other conditions.
Researchers show that infection by Zika caused death of cells from glioblastoma, the most common and aggressive kind of malignant brain tumor in adults. Scientists foresee the use of genetic engineering to neutralize Zika virus' infectious whilst preserving the viral particles which induce the death of tumoral cells.
The bacterium Streptomyces chartreusis is an antibiotic-producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. Many of the substances are likely released to mediate interactions with its environment. They might also include molecules that are of interest as potential pharmaceutical agents. A research team analysed a broad spectrum of the bacterium's metabolic products under various culture conditions.
For couples with decades of shared memories, a partner's decline in the ability to communicate because of dementia is frightening and frustrating. Communication strategies they've used before simply don't work anymore. By getting creative, an in-home intervention to support couples affected by dementia is showing that 'practice does make perfect,' both for the caregiver and the care receiver or person with dementia, and can improve their communication behaviors in just 10 weeks.
Prophylactic use of the drug haloperidol does not help to prevent delirium in intensive care patients or improve their chances of survival. Therefore, there is no reason anymore to administer the drug as a preventive measure to reduce the burden of delirium. This was revealed following a three-year, large-scale study among 1,800 patients in 20 Dutch ICUs.
A bone marrow transplant is often the only therapy available to save leukaemia patients, but the risk of complications is high. Nearly half of all patients experience an unwanted reaction of their immune system, which often attacks their skin and liver and in up to 50 percent of cases the intestines. Researchers have succeeded in deciphering what causes this in some instances life-threatening inflammation of the intestines.
People suffering from major depressive disorder, MDD, have reduced arginine levels, a new study shows.
Researchers use cutting-edge technologies to uncover differences in neural control for arms and legs.
Spending too much time in front of the television could increase your chance of developing potentially fatal blood clots known as venous thrombosis. Even trying to counterbalance hours of TV watching through adequate exercise is not effective warn researchers.
Scientists have identified a hormone that could help prepare the womb lining for pregnancy, research shows.
Treating food allergies might be a simple matter of teaching the immune system a new trick, researchers have found. In a study using mice bred to have peanut allergies, the researchers were able to reprogram the animals' immune systems using a nanoparticle delivery of molecules to the lymph nodes that switched off the life-threatening reactions to peanut exposures.
Some tropical birds have longer egg incubation times than their temperate cousins, even though their habitat is teeming with egg-eating predators. The reason why has long been a mystery, but a new study applies new methods to confirm the evidence for an old hypothesis -- that a longer development period leads to a stronger, more efficient immune system.
Evidence suggests that sipping wine may be good for your colon and heart, possibly because of the beverage's abundant and structurally diverse polyphenols. Now researchers report that wine polyphenols might also be good for your oral health.
New research sheds light on the effects of high blood pressure by considering the way the body responds to a lack of oxygen.
Modern humans have brains that are more than three times larger than our closest living relatives, chimpanzees and bonobos. Scientists don't agree on when and how this dramatic increase took place, but new analysis of 94 hominin fossils shows that average brain size increased gradually and consistently over the past three million years.
Axonal and dendritic proteins embedded in the membrane at either end -- called transmembrane proteins -- are built in the same cellular factory and travel on the same cellular highway. But for the cell to function property, they must be delivered to the correct domain. So how does the cell regulate that voyage?
A new study finds early dermatology consultation for presumptive cellulitis can improve patient outcomes, reduce costs and reduce hospitalization.
Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study of over one million adults diagnosed with dementia in France.
A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If the inflammation lingers, it can lead heart failure. The inflammation can also claim another victim -- the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a therapeutic dose, is able to limit this collateral damage in the kidneys, as tested in an animal model. This suggests potential application to the clinical setting.
Levels of a protein found in the brain called alpha-synuclein are significantly lower than normal in cerebrospinal fluid collected in Parkinson's disease patients suffering from postural instability and gait difficulty, a study has found.
How a person responds to a difficult life event such as a death or divorce helps shape the development of their wisdom over time, a new study suggests.
Our brains are wrinkled like walnuts by the time we are born. Babies born without these wrinkles -- called smooth brain syndrome -- suffer from severe developmental deficiencies and their life expectancy is markedly reduced. Now researchers have developed a method for growing tiny 'brains on chips' from human cells that enabled them to track the physical and biological mechanisms underlying the wrinkling process.
A microRNA that regulates inflammation shows promise as a treatment for inflammatory diseases such as asthma and cancer, according to new research.
Researchers suggest liquefied brain fluid may be one cause of dementia after stroke.
A new research report shows that a high ranking in the Human Development Index is connected with the availability of mental health services. In a comparison between 17 European and Asian countries, Norway, Switzerland and Finland had the highest ratio of child and adolescent psychiatrists.
Social media data can be used as an additional source of information to gauge public opinion about health issues alongside traditional data sources like phone-based polling, according to new research.
Australian biomedical engineers have developed a 3-D material that successfully mimics nature to transform cells into muscle.
Researchers have compiled, archived and shared one of the largest open-source data sets of brain scans from stroke patients. The data set, known as ATLAS, is available for download. Researchers globally are using the scans to develop and test algorithms that can automatically process MRI images from stroke patients. In the long run, scientists hope to identify biological markers that forecast which patients will respond to various rehabilitation therapies and personalize treatment plans.
Researchers have improved on the currently available methods for screening drugs for heart-related side effects. The method involves fabricating a tiny hole in a silicon chip over which lipid membranes, similar to those that surround cells, are encouraged to grow.
A new study is believed to be the first to show a higher risk of dementia in adults who were born with heart disease. The study of more than 10,000 adult with congenital heart disease (CHD) in Denmark discovered a particularly increased risk for early dementia in middle-age adults.
A new study identifies a novel treatment strategy that preserved neuromuscular synapses in a mouse model of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

Clinical/PICO Search

for DHA
Help?

Management/PICOC Search

for DHA
Help?
PubMed Logo