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Trigeminal neuralgia is characterized by sharp, lancinating pain in the teeth or facial area. The standard treatment for this chronic nerve pain can cause burdening side effects. A novel substance inhibits the pain effectively and is well tolerated, as documented by the initial results of an international study.
The metabolic state of tumor cells contributes to signals that control the proliferation of tumor cells. In the 1920s, scientists observed that tumor cells radically change their metabolism. This process was termed "Warburg Effect", however neglected until recently by cancer research, but the latest results show it is indeed of fundamental importance for the development of aggressive tumors.
Ticks are well known for their ability to anchor themselves firmly to the skin, so that they can suck blood for several days. This anchoring mechanism is so effective because it is based on a cement-like substance with excellent adhesive properties, so that it works like a dowel for the mouthparts of the tick. Researchers want to study this "tick cement" and recreate it chemically for use in biomaterial research.
If you know healthy eating is important for your kids, but you also feel like it's easier said than done, you're not alone. Many parents may not be following the recipe for encouraging healthy diets in their kids, and 1 in 5 don't think it's important to limit fast food and other junk food, outlines a new report.
Nearly one in four patients with incurable gastrointestinal stromal tumors (GIST) treated with Gleevec will survive 10 years, a new report outlines.
Nearly 70 percent of prescription opioid medications kept in homes with children are not stored safely, a new study finds.
Dentists aren't the only people who influence how we take care of our teeth; our friends and family play a big role, too.
A new biological-behavioral-operational computer model could help policy makers choose the best intervention strategies to rapidly contain an infectious disease outbreak. The model is based on the dynamics of disease transmission across different environments and social settings, and provides critical information about how to mitigate infection, monitor risk and trace disease during a pandemic.
Former NFL players who had repeated head injuries may not have significant problems with motor functions later in life, according to a preliminary study.
Some people can pass a hearing test but have trouble understanding speech in a noisy environment. New research identifies a new mechanism for this condition just years after its discovery.
Microbiologists have found a yeast in the gut of new babies in Ecuador that appears to be a strong predictor that they will develop asthma in childhood. The new research furthers our understanding of the role microscopic organisms play in our overall health.
Only 25% of patients respond to sorafenib treatment, so researchers have endeavored to understand its mechanism of action and discover a way to boost its effectiveness.
Lower levels of vitamin D in the blood increase the risk of clinical relapse in patients with Ulcerative Colitis (UC), an inflammatory bowel disease that causes long-lasting inflammation and ulcers in the colon, a new study has found.
A multidisciplinary team has uncovered the mechanisms that the Zika virus uses to alter brain development, outlines a new report.
The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes, new research has found.
Biomedical engineers have developed imaging technology that is the first to see DNA 'blink,' or fluoresce. The tool enables researchers to study individual biomolecules (DNA, chromatin, proteins) as well as important global patterns of gene expression, which could yield insights into cancer.
In a new study, researchers found for the first time that the neurotransmitter dopamine is involved in human bonding, bringing the brain's reward system into our understanding of how we form human attachments. The results, based on a study with 19 mother-infant pairs, have important implications for therapies addressing postpartum depression as well as disorders of the dopamine system such as Parkinson's disease, addiction, and social dysfunction.
A team has found a way to identify the small population of circulating helper T cells present in the blood after an annual flu vaccine to monitor their contribution to antibody strength. A technique that identifies these helper immune cells could inform future vaccine design, especially for vulnerable populations.
Excess lipoproteins and fatty acids may be associated with the development of painful and often chronic kidney stones in children, new research shows.
Empathy and emotional awareness do not affect our moral decisions, suggests a new study. Our choices do not depend on our empathy, say the authors, adding that the difference, instead, lies in our emotional reactions, more pronounced in more empathic people. In particular if we opt for uncomfortable decisions for a greater good.
Impaired movement control may result in chronic lower back pain. A new study shows that the combination of manual therapy and exercise is an excellent way to combat movement control impairment in the lower back. This combination reduced the disability experienced by patients and significantly improved their functional ability. A personally tailored exercise program was more beneficial for patients than a generic one, and the treatment results also persisted at a 12-month follow-up.
A genetic 'switch' has been discovered, which could help to prevent or delay the symptoms of Parkinson's disease, report scientists.
The cutting-edge biocompatible near-infrared 3-D tracking system used to guide the suturing in the first smart tissue autonomous robot (STAR) surgery has the potential to improve manual and robot-assisted surgery and interventions through unobstructed 3-D visibility and enhanced accuracy, according to a new study.
Adult stem cells collected directly from human fat are more stable than other cells -- such as fibroblasts from the skin -- and have the potential for use in anti-aging treatments, according to researchers.
Researchers have developed an improved type of electrode that is more durable, lasts longer in the body and transmits a clearer, more robust signal than electrodes made from current state-of-the-art materials. This could allow for improved restoration of mobility after spinal cord accidents, as well as improved powered prosthetic limbs.
About 2 percent of domestic-violence incidents involve guns, according to new research. Victims of these crimes typically have fewer injuries but more fear. These findings come as part of her latest work, which looks at how frequently guns and other weapon types appear in domestic-violence incidents.
A tumor suppressor protein thought to prevent acute myeloid leukemia (AML) can actually promote a particularly deadly form of the disease, researchers have discovered. The study suggests that targeting this protein could be an effective treatment for certain AML patients.
Does a stay in the intensive care unit give patients a better chance of surviving a chronic obstructive pulmonary disease (COPD) or heart failure flare-up or even a heart attack, compared with care in another type of hospital unit? Unless a patient is clearly critically ill, the answer may be no, according to researchers who analyzed more than 1.5 million Medicare records.
Fathers given boosts of the hormone oxytocin show increased activity in brain regions associated with reward and empathy when viewing photos of their toddlers, a new study finds.
Researchers present a new method that should enable controlled drug delivery into the bloodstream using DNA computers. The team developed the first DNA computer capable of detecting several antibodies in the blood and performing subsequent calculations based on this input. This is an important step towards the development of smart, 'intelligent' drugs that may allow better control of medication with fewer side-effects and at lower cost.
Mothers who want the benefits of breast milk for their babies but can't produce the substance often turn to milk-sharing networks. A new study has found that although not a recommended practice, those who participate in milk-sharing networks generally follow good hygiene, which is critical for keeping milk free from bacterial contamination.
It is not the brain that determines if people are right or left-handed, but the spinal cord, new research indicates. The biopsychologists have demonstrated that gene activity in the spinal cord is asymmetrical already in the womb.
In 1932 T.S. Eliot famously argued, 'Genuine poetry can communicate before it is understood.' But can we really appreciate the musical sound of poetry independent of its literary meaning? Apparently yes. A recent study has shown that the brain displays a positive electrophysiological response when presented with sentences that conform to certain poetic construction rules. It is the first demonstration of unconscious processing of poetic constructs by the brain.
Walking for just 30 minutes three times per week could improve the quality of life for those with advanced cancer, a new study has found.
The role of a protein called PAK4 in the movement and growth of pancreatic cancer cells could help researchers find new ways to tackle the disease, a new study that confirms.
The average news consumer might be surprised to learn that the economic costs of alcohol abuse far exceed those related to illegal drug use. In California, alcohol abuse cost $129 billion in 2010, $450 per California resident. That was almost three times the $44 billion bill for illicit drug use. The largest cost contributors were mortality, impaired driving, and violence. The costs varied greatly from city to city and county to county.
Receiving advice on limiting salt consumption helped kidney disease patients lower their systolic blood pressure by an average of 11 mmHg, research concludes. Limiting salt intake also reduced excess fluid retention that is common among patients with kidney disease.
Antibiotics are illegally available without prescription on 45 per cent of online pharmacy websites surveyed, scientists have found.
Few Armed Forces personnel seek help for mental health disorders and novel approaches will be needed to encourage personnel at risk of PTSD, anxiety and alcohol abuse to seek treatment, suggests a new study. A trial testing a potential post-deployment screening program for UK Armed Forces personnel, based on a computerized assessment and tailored mental health advice, found it was not effective in reducing symptoms of mental health disorders or encouraging personnel to seek help, compared to the general mental health advice which is the standard of care in the UK military.
A mutation in the hemoglobin of a young woman in Germany was found to cause her mild anemia. But her father, who shared the mutation, did not develop anemia because his mutant hemoglobin was stabilized by carbon monoxide produced from his smoking.
Screen time before bed can mess with your sleep. But people without TV and laptops skimp on sleep too, researchers say. A study of people living without electricity or artificial light in a remote farming village in Madagascar finds they get shorter, poorer sleep than people in the US or Europe. But they seem to make up for lost shuteye with a more regular sleep routine, the researchers report.
A component of an enzyme family linked to DNA repair, stress responses, and cancer also plays a role in enhancing or inhibiting major cellular activities under physiological conditions, new research shows.
Scientists have mapped a vast spider web of interactions between proteins in lung cancer cells, as part of an effort to reach what was considered 'undruggable.' This approach revealed new ways to target cells carrying mutations in cancer-causing genes.
Scientists have known for decades that drastically restricting certain nutrients without causing malnutrition prolongs health and lifespan in a wide range of species, but the molecular mechanisms underlying this effect have remained a mystery. Now new research sheds light on an important genetic pathway underlying this effect, raising the possibility that therapies can be developed to prolong healthy human lifespan.
New research provides insight into the importance of song for infants and mothers. The work explored the role of infant-directed singing in relation to intricate bond between mother and infant.
The ability of small intestine cells to absorb nutrients and act as a barrier to pathogens is 'significantly decreased' after chronic exposure to nanoparticles of titanium dioxide, a common food additive found in everything from chewing gum to bread, according to new research.
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial scourge that is resistant to most common antibiotics and thus difficult to treat, particularly in children where it commonly causes complicated skin and skin structure infections. In a randomized, controlled clinical trial -- the first of its kind -- a multi-institution research team reports that daptomycin, part of a new class of antibiotics currently approved only for use in adults, is effective and well-tolerated in children.
Nonsense-mediated RNA decay (NMD) is a processing pathway in cells that, like a broom, cleans up erroneous RNA. Biomedical scientists report that they have come up with a method in the lab that detects NMD efficiency inside the cell.
Antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery, a systematic review of existing literature concludes.
Many who have a chronic traumatic brain injury (TBI) report struggling to solve problems, understand complex information and maintain friendships, despite scoring normally on cognitive tests. New research finds that a gist reasoning test, developed by clinicians and cognitive neuroscientists, is more sensitive than other traditional tests at identifying certain cognitive deficits.
Black girls are disproportionately punished in American schools -- an 'overlooked crisis' that is populating the school-to-prison pipeline at rising rates, two education scholars argue in a new paper.
A collaboration between chemists and gene therapy experts produced a new way of inserting the code for modified proteins into the cells of mice. If successful in humans, the technique could be useful for vaccines or cancer therapies.
How international university students think about home significantly influences their migration plans upon graduation, according to a new study.
Social exclusion leads to conspiratorial thinking, research shows. Feelings of despair brought on by social exclusion can cause people to seek meaning in miraculous stories, which may not necessarily be true.
An immune system proteinase called granzyme A appears to promote arthritic inflammation in mice infected with chikungunya virus, scientists report. The study also suggested that granzyme A could serve as a potential target for new drugs to treat chikungunya and related viral arthritides in people.
Scientists have discovered that a common type of cell within the human reproductive and intestinal tracts assists HIV in infecting immune cells. Understanding how these cells aid HIV could lead to new methods that prevent HIV transmission.
The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists have found that even the one-off consumption of a greater amount of palm oil reduces the body's sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver.
Seeing is not always believing -- visual speech (mouth movements) mismatched with auditory speech (sounds) can result in the perception of an entirely different message. This mysterious illusion is known as the McGurk effect. Neuroscience researchers have created an algorithm to reveal key insight into why the brain can sometimes muddle up one of the most fundamental aspects of the human experience.
In a crowded marketplace of products advertised to repel mosquitoes, consumers are wise to trust spray-on repellents containing DEET or PMD, say researchers. In a comparison study of several mosquito-repellent products, 'wearable' devices such as bracelets or sonic repellers were found to be largely ineffective in repelling Aedes aegypti mosquitoes.
A mutation that impacts changes in the shape of an essential viral protein may influence the infectivity of West Nile and other viruses in the flavivirus family, according to a new study.

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